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The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased testicular testosterone in those treated with 0.3 μg/kg. Decreased 3β-HSD1 at 1.0 μg/kg exposure levels

Subjects: Sprague Dawley rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.3 or 1.0 μg/kg bw

Route of administration: dissolved in corn oil and administered orally

Exposure duration: gestational day 11 – single dose (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 4)

Age of measurement: gestational day 19.5

Reference [PubMed Link]
Adamsson A, Simanainen U, Viluksela M, Paranko J, Toppari J. 2009. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis. Int J Androl 32(5):575-585.