The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased percent incidence of eruption of lower incisors |
Subjects: Line C (highly sensitive to TCDD) rats Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and delivered orally Exposure duration: 2 days of age – single dose (comparable to human prenatal development from approximately day 1 of week 21 to day 1 of week 22) Age of measurement: 40 days of age |
Reference [PubMed Link] Miettinen HM, Alaluusua S, Tuomisto J, Viluksela M. 2002. Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: The role of exposure time. Toxicol Appl Pharmacol 184(1):57-66. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased length of femur, periosteal circumference (PERI), and polar cross-sectional moment of inertia (PMI) of femur in line C males at 1.0 μg/kg; decreased PERI and PMI of female tibia, and PMI of female femur in line C rats at 1.0 μg/kg |
Subjects: Line A (least sensitive to TCDD), B, and C (most sensitive) rats Chemical: Dioxin (TCDD) Low doses tested: 0.03, 0.1, 0.3, or 1.0 μg/kg bw; exposure timing study Route of administration: dissolved in corn oil and delivered orally Exposure duration: 2 days of age – single dose (comparable to human prenatal development from approximately day 1 of week 21 to day 1 of week 22) Age of measurement: 40 days of age |
Reference [PubMed Link] Miettinen HM, Pulkkinen P, Jamsa T, Koistinen J, Simanainen U, Tuomisto J, Tuukkanen J, Viluksela M. 2005. Effects of in utero and lactational TCDD exposure on bone development in differentially sensitive rat lines. Toxicol Sci 85(2):1003-1012. |